Intravenous dexmedetomidine versus esmolol for attenuation of haemodynamic response to endotracheal extubation: A randomized double-blind study

Background and Aim: Tracheal extubation is a crucial step of general anaesthesia which associated with intense airway hemodynamic responses secondary to activation mechanoreceptors in larynx. The present study aims compare the efficacy intravenously administered dexmedetomidine esmolol attenuating response endotracheal extubation. Materials Method: This prospective, randomized, double-blind was conducted 80 ASA I-II patients 18-60 years undergoing elective surgery under anaesthesia. They were randomly divided into two groups forty each. Anticipated ten minutes before Group D received intravenous 0.5 µg/kg diluted 10 ml normal saline E saline. Two min bolus dose 1 mg/kg Heart rate, systolic blood pressure, diastolic mean emergence time, Ramsay sedation score adverse events recorded. Results: Mean heart rate significantly lower group from 5 drug administration till 20 post as compared E. pressure 8 after (p<0.05). Emergence time comparable both (p>0.05). Delayed observed 2 D. More number sedated. Conclusion: IV better haemodynamic than because comparatively stable haemodynamics, conscious sedation, less postoperative cough agitation.